Zhenyi Wu

This study performs a single-nucleus transcriptome-wide association study to identify gene-trait associations in brain disorders, revealing cell-type-specific genetic regulation and ancestry-specific patterns.

The paper constructs a single-nucleus atlas of genetic regulation in the human brain, identifying cell-type-specific regulatory effects and disease-associated genes.

This paper presents a computational drug repurposing framework that identifies FDA-approved drugs for COVID-19 by integrating genetic expression data and EMR data, finding four compounds with protective effects in validation.

The paper identifies 60 genetic loci associated with brain ventricular and subcortical shape features using shape measures from over 45,000 UK Biobank and ABCD study subjects.

The paper investigates phenotypic and genetic links between heart and brain using MRI data from 40,000 UK Biobank subjects, finding strong correlations and shared genetic influences.

This study identifies genetic loci associated with functional brain networks and areas using large-scale fMRI data, linking them to cognitive traits and brain disorders.