Author

Grant C. O’Connell

West Virginia UniversityORCID 0000-0002-2642-6670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Paul David ChantleriD· 2 shared Taura L. BarriD· 2 shared Abdul TarabishyiD· 1 shared Chris WinkelmaniD· 1 shared Christine G. SmothersiD· 1 shared Connie S. Tennant· 1 shared Noelle Lucke-WoldiD· 1 shared Yasser Kabbani· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Paul David ChantlerORCID

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3 papers

Recent·Most cited

NeuroscienceBrain InjuryPeer-reviewedJun 4, 2020

Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers.

Grant C. O’Connell, Christine G. Smothers, Chris Winkelman

The paper identifies five brain-specific miRNAs that are elevated in serum of TBI patients and can distinguish TBI cases from controls with high sensitivity and specificity.

43 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceScientific ReportsPeer-reviewedOct 5, 2017

Monocyte-Lymphocyte Cross-Communication Via Soluble CD163 Directly Links Innate Immune System Activation And Adaptive Immune System Suppression Following Ischemic Stroke

Grant C. O’Connell, Connie S. Tennant, Noelle Lucke-Wold…·Taura L. Barr

This study shows that soluble CD163 from activated monocytes suppresses lymphocytes after ischemic stroke, linking innate immune activation to adaptive immune suppression.

33 citations

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsGenomics DataPeer-reviewedSep 1, 2017

Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population.

Grant C. O’Connell, Paul David Chantler, Taura L. Barr

The paper validates a previously identified ten-gene expression pattern for stroke detection in an independent cohort, showing high sensitivity and specificity across multiple time points.

37 citations

humanbulk RNA-seq

𝕏 PostBluesky