BiochemistryFitoterapiaPeer-reviewed
Mechanistic Insights into the Inhibition of Recombinant Hepatitis E Virus Papain-like Cysteine Protease by Khaya grandifoliola Hydro-Ethanolic Extract: UHPLC-MS Profiling, Enzyme Kinetics, Computational Modeling, and Cell-Based Assays
Arnaud Fondjo Kouam, Cromwel Tepap Zemnou, Armel Jackson Seukep…·Paul Fewou Moundipa
This study identifies Khaya grandifoliola hydro-ethanolic extract as a potent inhibitor of HEV-PLpro protease, with anti-HEV activity comparable to ribavirin and no cytotoxicity.
DOI 10.1016/j.fitote.2026.107335