Mário Grãos

This study shows that soft extracellular matrix reduces autophagic flux and disrupts redox balance in neuronal cells, mimicking neurodegenerative disease features.

This study shows that physioxia-modulated UC-MSC secretome better preserves neuronal network and translation processes in an in vitro HIE model than traditional UC-MSCs.

This study shows that culturing mesenchymal stem cells under physiological stiffness and oxygen conditions increases secretion of redox and immunomodulatory proteins while reducing extracellular matrix proteins.

This paper shows that culturing MSCs on soft substrates or under low oxygen levels alters their proteome, promoting a more naive phenotype by affecting redox homeostasis, protein chaperones, and translational complexity.