A novel equilibrative nucleoside transporter 1 inhibitor alleviates Tau-mediated neurodegeneration
Ching‐Pang Chang, Ya‐Gin Chang, Pei‐Yun Chuang, Thi Ngoc Anh Nguyen, Fang-Yi Chou, Sin‐Jhong Cheng, Hui‐Mei Chen, Lee‐Way Jin, Kévin Carvalho, Vincent Huin, Luc Buée, David L Blum, Yung‐Feng Liao, Chun‐Jung Lin, Yijuang Chern
This study shows that inhibiting ENT1 with J4 reduces Tau-mediated neurodegeneration in a mouse model by improving energy homeostasis and mitigating immune responses.
bioRxiv · Oct 25, 2020 · PreprintNeuroscience