Yijuang Chern

This study identifies CD22 upregulation in microglia due to oxidative stress in HD, which impairs phagocytosis and worsens disease progression.

This paper introduces dodecagon light-sheet fluorescence microscopy (dodecaLSFM) to eliminate striping artifacts in large-volume imaging, demonstrating its effectiveness in imaging whole mouse brain vasculature and combining with expansion microscopy for 3D cellular resolution.

This study shows that inhibiting ENT1 with J4 reduces Tau-mediated neurodegeneration in a mouse model by improving energy homeostasis and mitigating immune responses.

This study shows neurodegeneration triggers MBNL2 degradation via calpain-2, reverting RNA processing to developmental patterns, and identifies this as a potential common mechanism in neurodegenerative diseases.