Örjan Carlborg

Low-coverage sequencing in a deep intercross of the Virginia body weight lines provides insight to the polygenic genetic architecture of growth: novel loci revealed by increased power and improved genome-coverage

This study uses low-coverage sequencing across multiple generations of a chicken intercross to identify novel minor-effect QTL contributing to body weight, increasing power and explaining more phenotypic variance.

Genotyping by low-coverage whole-genome sequencing in intercross pedigrees from outbred founders: a cost efficient approach

The paper describes a method for high-resolution genotype imputation in outbred intercrosses using low-coverage whole-genome sequencing and evaluates it in a chicken F2 pedigree.

Yeast growth responses to environmental perturbations are associated with rewiring of large epistatic networks

The paper examines how environmental changes affect genetic interaction networks in yeast, showing that hub loci modulate phenotypic effects depending on environmental context.

Bidirectional selection for body weight on standing genetic variation in a chicken model

The paper examines genomic signatures of bidirectional selection in chicken lines and finds that selection on standing genetic variation leads to diverse haplotype patterns.

On the relationship between high-order linkage disequilibrium and epistasis

The paper evaluates the prevalence of high-order linkage disequilibrium as an explanation for statistical epistasis in genome-wide association studies using A. thaliana data.

Explorations of the polygenic genetic architecture of flowering time in the worldwide Arabidopsis thaliana population

This study investigates how 48 flowering time loci contribute to genetic differences among Arabidopsis thaliana subpopulations across ecological habitats, revealing polygenic adaptation and gene-by-temperature interactions.

A multi-locus association analysis method integrating phenotype and expression data reveals multiple novel associations to flowering time variation in wild-collected Arabidopsis thaliana

On The Relationship Between Epistasis And Genetic Variance-Heterogeneity

The paper explores the relationship between epistasis and genetic variance heterogeneity using theoretical and empirical analyses.

Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast

The paper shows that accounting for genetic interactions improves modeling of quantitative trait phenotypes in yeast by considering epistatic networks and allele frequencies.

A complex multi-locus, multi-allelic genetic architecture underlying the long-term selection-response in the Virginia body weight line of chickens

The paper investigates the genetic architecture of long-term selection responses in Virginia chicken lines, identifying multiple loci and genetic mechanisms contributing to body weight variation.

Standing genetic variation as a major contributor to adaptation in the Virginia chicken lines selection experiment

The paper identifies adaptive selective-sweeps in Virginia chicken lines and shows they contribute significantly to body-weight divergence and genetic variance.

A Genome-Wide Association Analysis Reveals Epistatic Cancellation of Additive Genetic Variance for Root Length in Arabidopsis thaliana

This paper identifies epistatic genetic interactions underlying root length variation in Arabidopsis thaliana, revealing that epistasis cancels additive genetic variance, and discovers functional candidate genes.

Natural CMT2 variation is associated with genome-wide methylation changes and temperature seasonality

The paper identifies CMT2 genetic variation linked to methylation changes and temperature adaptation in Arabidopsis thaliana using a novel genome-wide association method.