Molecular BiologyeLifePeer-reviewed
An Entropic Safety Catch Controls Hepatitis C Virus Entry and Antibody Resistance.
Lenka Stejskal, Mphatso D. Kalemera, Charlotte B. Lewis…·Joe Grove
This study identifies HVR-1 as an autoinhibitory region in HCV E1E2 that suppresses viral entry through conformational entropy, which is released upon receptor binding to enhance entry but reduce antibody resistance.