Enhanced inter-chain hydrogen bonding in the murine norovirus VP1 capsid leads to increased particle stability and delayed viral uncoating
Jake T. Mills, Charlotte B. Lewis, Lee Sherry…·Morgan R. Herod
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MRC University of Glasgow Centre for Virus ResearchORCID 0000-0003-0918-9201Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Jake T. Mills, Charlotte B. Lewis, Lee Sherry…·Morgan R. Herod
Charlotte B. Lewis, Lee Sherry, Rochelle McGrory…·David Bhella
This study demonstrates that inhibiting VP2-mediated entry reduces calicivirus infectivity, suggesting a potential antiviral strategy for treating norovirus disease.
Lenka Stejskal, Mphatso D. Kalemera, Charlotte B. Lewis…·Joe Grove
This study identifies HVR-1 as an autoinhibitory region in HCV E1E2 that suppresses viral entry through conformational entropy, which is released upon receptor binding to enhance entry but reduce antibody resistance.