Joe Grove

The paper predicts quaternary structures of viral proteins using AlphaFold2 and AlphaFold-Multimer, identifying new insights into vaccinology and protease targets.

This study shows that the SARS-CoV-2 Spike H655Y mutation changes protease preference but does not determine cellular tropism, with RBD interactions being more critical for upper airway adaptation.

This study demonstrates that inhibiting VP2-mediated entry reduces calicivirus infectivity, suggesting a potential antiviral strategy for treating norovirus disease.

The paper uses cryo-EM to determine the structure of Ictalurid herpesvirus 1, revealing conserved and novel features including a portal-vertex tegument protein with multiple macrodomain-like folds.

This study compares antiviral and cytolytic responses in primary human hepatocytes to YFV vaccine and virulent strains, finding similar propagation kinetics but distinct transcriptional responses.

Viro3D predicts and curates protein structures for 4,400 viruses, expanding structural coverage 30-fold and enabling functional and evolutionary analysis of viral proteins.

The paper isolates a new jingchuvirus, TDCV, from Tasmanian devil tumor cells, showing it infects these cells but not mosquito cells, and suggests it belongs to a novel virus family.

The paper analyzes tunicate metatranscriptomes to show that some disease-causing RNA viruses evolved before vertebrates and that recombination between viral orders shaped their evolution.

The paper redefines the taxonomy of Flaviviridae by integrating protein sequence and structure data, revealing new clades and expanding host range.

The paper maps glycoprotein structures across Flaviviridae to identify evolutionary events shaping their virology and ecology.

This paper creates a mouse model of pegivirus infection and investigates immune mechanisms of persistence and cross-species infection.

This paper identifies a 39.8kb flavi-like virus without an exonuclease that overcomes the RNA virus error threshold by using bacterial nucleic acid metabolism domains.

This paper shows that protein language models can assess mutation effects in SARS-CoV-2 spike protein without multiple sequence alignments, capturing evolutionary constraints and variant properties.

This study identifies HVR-1 as an autoinhibitory region in HCV E1E2 that suppresses viral entry through conformational entropy, which is released upon receptor binding to enhance entry but reduce antibody resistance.

This study investigates how CD81 senses cholesterol and how this affects its function as a hepatitis C virus receptor, finding that cholesterol binding regulates CD81's conformation and receptor activity.

This paper introduces a method combining fluorescence microscopy and statistical modeling to accurately determine the stoichiometry of bio-molecular complexes.