B cells imprinted by ancestral SARS-CoV-2 develop pan-sarbecovirus neutralization in immune recalls
Xixian Chen, Ling Li, Ruiping Du, Zuowei Wang, Yunjian Li, Yi Sun, Rongrong Qin, Hualong Feng, Lin Hu, Xuanyi Chen, Maosheng Lu, Xueyan Huang, Liwei Jiang, Teng Zuo
The paper shows that B cells from ancestral SARS-CoV-2 infections can develop broad neutralization against multiple sarbecoviruses after repeated immune challenges.
bioRxiv · Oct 13, 2024 · PreprintImmunology