Heterobifunctional proteomimetic polymers for targeted protein degradation
Max Mu Wang, Mihai Ioan Truica, Brayley S. Gattis, Julia Oktawiec, Vinay Sagar, Ananya A. Basu, Paul A. Bertin, Xiaoyu Zhang, Sarki Abba Abdulkadir, Nathan C. Gianneschi
This paper introduces HYDRAC, a polymer-based platform for targeted protein degradation, demonstrating its effectiveness in degrading MYC and KRAS in vitro and in vivo.
bioRxiv · Mar 7, 2025 · PreprintBioengineering