Nathan C. Gianneschi

This study examines peptide-brush polymers mimicking protein structure, finding that polymer backbones disrupt secondary structures and alter free-energy landscapes.

This study develops a proteomimetic polymer based on angiotensin-(1-7) for topical treatment of corneal injury, showing reduced inflammation, edema, and neovascularization in a mouse model.

This paper introduces HYDRAC, a polymer-based platform for targeted protein degradation, demonstrating its effectiveness in degrading MYC and KRAS in vitro and in vivo.

This paper develops a protein-like polymer that inhibits tau fibril propagation in human-derived models of neurodegeneration by targeting a specific structural motif of 4R tau isoforms.

The paper uses a genome-wide CRISPR/Cas9 knockout screen to identify novel transporters involved in nanoparticle uptake, finding SLC18B1 mediates polymeric micellar nanoparticle uptake.