Author

Kathleen J. Sweadner

Harvard UniversityORCID 0000-0002-2817-5262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Elena ArystarkhovaiD· 2 shared Aamir R. ZuberiiD· 1 shared Allison BrasheariD· 1 shared Aloysius DomingoiD· 1 shared Ari Dehn· 1 shared Arn M. J. M. van den MaagdenbergiD· 1 shared Cathleen M. LutziD· 1 shared David A. KnowlesiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Elena ArystarkhovaORCID

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2 papers

Recent·Most cited

What is pathogenicity? Structural vulnerabilities lead to distinct phenotypes in a membrane protein, ATP1A3

Kathleen J. Sweadner, Laurie J. Ozelius, Aloysius Domingo, Kotchaphorn Mangkalaphiban, Ihtsham ul Haq, Allison Brashear, Elena Arystarkhova

The paper identifies structural vulnerabilities in ATP1A3 variants that lead to distinct neurological phenotypes through different mechanistic consequences.

bioRxiv · Oct 15, 2026 · PreprintNeuroscience

Alternating hemiplegia of childhood associated mutations in Atp1a3 reveal diverse neurological alterations in mice.

Markus Terrey, Georgii Krivoshein, Scott I. Adamson, Elena Arystarkhova, Laura C. Anderson, John Szwec, Shelby McKee, Holly Jones, Sara Perkins, Vijay Selvam, Pierre-Alexandre Piec, Dweet Chhaya, Ari Dehn, Aamir R. Zuberi, Stephen A. Murray, , Cathleen M. Lutz

This study investigates the effects of two common Atp1a3 mutations in mice, revealing distinct neurological phenotypes and potential therapeutic avenues for alternating hemiplegia of childhood.

bioRxiv · Dec 24, 2024 · PreprintNeuroscience