Author

Kotchaphorn Mangkalaphiban

University of Massachusetts Chan Medical SchoolORCID 0000-0002-5341-9329Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetic & Genomic Medicine· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Allan JacobsoniD· 3 shared Robin GanesaniD· 3 shared Aloysius DomingoiD· 2 shared Feng HeiD· 2 shared Laurie J. OzeliusiD· 2 shared Allison BrasheariD· 1 shared Bailey Reese· 1 shared Chan WuiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMolecular Biology

Allan JacobsonORCID

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Author profile →

5 papers

Recent·Most cited

Perisynaptic matrix gene variants underlie DystoniaGeneNet endophenotypes in isolated focal dystonia

Aloysius Domingo, Dongren Yao, Nyah Kshatriya, Kotchaphorn Mangkalaphiban, Giovanni Battistella, Lena C. O’Flynn, Bailey Reese, Madison Hincher, Rachita Yadav, Nutan Sharma, Laura Williams, Conor Fearon, Owen Killian, Richard B. Reilly, Michael Hutchinson, , Laurie J. Ozelius

This paper uses a deep learning model to identify genetic variants associated with isolated focal dystonia by leveraging neuroimaging endophenotypes.

medRxiv · Oct 21, 2026 · PreprintGenetic & Genomic Medicine

What is pathogenicity? Structural vulnerabilities lead to distinct phenotypes in a membrane protein, ATP1A3

Kathleen J. Sweadner, Laurie J. Ozelius, Aloysius Domingo, Kotchaphorn Mangkalaphiban, Ihtsham ul Haq, Allison Brashear, Elena Arystarkhova

The paper identifies structural vulnerabilities in ATP1A3 variants that lead to distinct neurological phenotypes through different mechanistic consequences.

bioRxiv · Oct 15, 2026 · PreprintNeuroscience

Direct and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay

Kotchaphorn Mangkalaphiban, Robin Ganesan, Allan Jacobson

This study examines the effects of PAB1 deletion in yeast on translation initiation, termination, and mRNA decay using RNA-Seq, Ribo-Seq, and mass spectrometry, revealing both direct and indirect consequences.

bioRxiv · May 31, 2023 · PreprintMolecular Biology

Progressive polysomal association of Upf1, Upf2, and Upf3 as ribosomes traverse mRNA coding regions

Robin Ganesan, Kotchaphorn Mangkalaphiban, Richard E. Baker, Feng He, Allan Jacobson

The paper investigates the timing and nature of Upf1, Upf2, and Upf3 ribosome association during NMD, revealing progressive polysome association and an early Upf1:80S complex.

bioRxiv · Dec 3, 2021 · PreprintMolecular Biology

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae

Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard Baker, Allan Jacobson

The paper investigates stop codon readthrough in yeast using ribosome profiling and bioinformatics to identify mRNA features influencing termination efficiency.

PLoS Genetics · Apr 20, 2021Peer-reviewedGenetics