Juan M. Corchado

Biohybrid restoration of the hippocampal loop re-establishes the non-seizing state in an in vitro model of limbic seizures

This paper evaluates an artificial bridge that restores hippocampal loop function in an in vitro model of limbic seizures, reducing ictal activity and restoring connectivity.

The intrinsic clock of the hippocampal subfield CA3 rescues limbic seizures in a biohybrid graft-host interaction in vitro

This paper demonstrates that interictal activity from hippocampal CA3 grafts can control limbic seizures in a biohybrid graft-host setup in vitro.

Developing hippocampal spheroids model ictogenesis and epileptogenesis

This study shows that rodent hippocampal spheroids spontaneously develop epileptiform activity, resembling human and animal epilepsy models, and highlights potential risks of cell-based therapies.