Michela Chiappalone

This study develops human neurospheroids to model cortical complexity, finding that three-dimensionality and modularity enhance network activity richness and complexity.

This study compares three metabolic stress models on human-derived neuronal networks, showing distinct effects on activity and viability, with limited recovery after reoxygenation.

This study investigates how ischemic lesions disrupt sleep-related cortical activity across multiple scales in rats, revealing stage-specific alterations in sleep-wake cycle dynamics and neural coordination.

This paper introduces two Python tools, spikeNburst and nicespike, for analyzing HD-MEA data, improving spike sorting and synchronization analysis.

The paper introduces BioemuS, a real-time biomimetic spiking neural network system for biohybrid experiments and emulation, aiming to advance neuroprosthetic development.

This paper evaluates an artificial bridge that restores hippocampal loop function in an in vitro model of limbic seizures, reducing ictal activity and restoring connectivity.

The paper shows that adult mice and human neurons have heterogeneous GABAergic responses, with DS mice showing higher depolarizing responses and behavioral rescue upon normalization.

This paper demonstrates that interictal activity from hippocampal CA3 grafts can control limbic seizures in a biohybrid graft-host setup in vitro.

This study investigates the spectral features of the brain's meso-scale structure at rest, finding frequency-specific organization patterns across different brain regions.

This study compares activity-dependent stimulation (ADS) to random stimulation (RS) in rats, showing ADS modulates firing properties and promotes synaptogenesis in the somatosensory area.

This paper proposes a neuromorphic system for real-time burst detection in neuronal cultures, achieving comparable performance to conventional methods with lower power and latency.

This study uses hdEEG to analyze neural oscillations during working memory tasks, identifying specific spectral patterns associated with update, maintenance, and readout phases.

This study compares open-loop and closed-loop intracortical microstimulation in rats, finding that activity-dependent stimulation more effectively increases short-latency evoked spikes in distant cortical areas.

This study investigates the role of Snord116 in regulating sleep patterns and cortical neuronal activity in a PWS mouse model, finding abnormalities in REM sleep and sleep spindles.

This paper demonstrates a neuromorphic prosthesis that restores bidirectional communication between disconnected neuronal populations in vitro.

The paper studies spontaneous dynamics in in vitro neuronal networks to identify intrinsic memory phenomena through analysis of functional connectivity and event similarity.