Synthetic BiologybioRxivPreprint
Stacking effects on mutation detection by T4 DNA ligation within dimeric DNA origami triangle barcodes for single-molecule nanopore analysis
Dorothy Aboagye-Mensah, Samuel Confederat, Fahad Alammar…·Matteo Castronovo
This paper develops a method using DNA origami barcodes and T4 DNA ligation to detect DNA point mutations with nanopore analysis, showing enhanced stacking effects that influence ligation efficiency.
DOI 10.1101/2024.01.09.574918