William R. Milligan

Dynamics of mutators of arbitrary dominance in humans

The paper develops a population genetic model to analyze mutator alleles in humans, showing that most known mutators are consistent with purifying selection, but one variant remains unexplained.

When should adaptation arise from a polygenic response versus few large effect changes?

This paper investigates when adaptation arises from polygenic responses versus few large effect changes by modeling trait genetics and ecological factors.

Disentangling sources of clock-like mutations in germline and soma

The paper develops a mathematical model to disentangle the sources of clock-like mutations in germline and soma, finding distinct origins for SBS signatures 1 and 5.