Natanael Spisak

What sets the mutation rate of a cell type in an animal species?

The paper reviews patterns and theories on how natural selection shapes mutation rates in animal germline and somatic cells across species.

Sex differences in transcription-associated mutagenesis in the human germline

The paper investigates sex differences in germline mutation rates linked to transcription, finding distinct associations in males and females across different germline stages.

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

The paper identifies SBS5 as a mutational signature resulting from DNA damage and repair errors across cell types, showing it is a common output of multiple mutagenic processes.

Disentangling sources of clock-like mutations in germline and soma

The paper develops a mathematical model to disentangle the sources of clock-like mutations in germline and soma, finding distinct origins for SBS signatures 1 and 5.