Marc de Manuel

What sets the mutation rate of a cell type in an animal species?

The paper reviews patterns and theories on how natural selection shapes mutation rates in animal germline and somatic cells across species.

Sex differences in transcription-associated mutagenesis in the human germline

The paper investigates sex differences in germline mutation rates linked to transcription, finding distinct associations in males and females across different germline stages.

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

The paper identifies SBS5 as a mutational signature resulting from DNA damage and repair errors across cell types, showing it is a common output of multiple mutagenic processes.

Mutation and recombination parameters in zebra finch are similar to those in mammals

This study estimates mutation and recombination parameters in zebra finches, finding similarities to mammals despite differences in genome structure and recombination mechanisms.

Disentangling sources of clock-like mutations in germline and soma

The paper develops a mathematical model to disentangle the sources of clock-like mutations in germline and soma, finding distinct origins for SBS signatures 1 and 5.

Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)

This study sequenced the genomes of two Arabian leopards, revealing population decline, inbreeding, and purging of deleterious mutations, and highlights the need for more genetic data to inform conservation efforts.

Estimates of genetic load suggest frequent purging of deleterious alleles in small populations

The paper estimates genetic load in mammals and finds that species with small population sizes and low diversity have lower genetic load due to purging of deleterious alleles.

The evolution of ecological flexibility, large brains, and long lives: capuchin monkey genomics revealed with fecalFACS

This study presents the first genome annotation of a capuchin monkey and identifies genes under positive selection related to longevity, brain development, and adaptation to diverse environments.

Plasmodium vivax Malaria viewed through the lens of an eradicated European strain

The paper generates a genome from a historical European Plasmodium vivax strain, revealing its evolutionary relationship to American strains and the presence of drug resistance variants predating their use.