Author

Ruben L. Smeets

Radboud University Medical CenterORCID 0000-0002-2862-1058Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexander HoischeniD· 2 shared Caspar I. van der MadeiD· 2 shared Hans J. P. M. KoeneniD· 2 shared Alfredo Cabrera‐OreficeiD· 1 shared Anne HebertiD· 1 shared Annet SimonsiD· 1 shared Arjan van Caam· 1 shared Bente SiebelsiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Alexander HoischenORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 23, 2026

Imaging guided single-cell multiomics unveils shared autoreactive CD4+ T-cell responses in blood, locoregional lymph node and affected tissues of patients with systemic autoimmunity

Theodoros Ioannis Papadimitriou, Prashant Singh, Arjan van Caam…·Rogier M. Thurlings

The paper uses imaging-guided single-cell multiomics to identify shared autoreactive CD4+ T-cell responses in blood, lymph nodes, and tissues of patients with systemic autoimmune diseases.

DOI 10.64898/2026.08.18.745406

humanscRNA-seq

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintJun 25, 2025

Complexome profiling showed impaired immunoproteasome assembly in a novel PRAAS subtype caused by monoallelic PSMB8 variants

Robin Wijngaard, Caspar I. van der Made, Sema Kalkan Uçar…·Sergio Guerrero‐Castillo

The paper identifies monoallelic PSMB8 variants causing impaired immunoproteasome assembly and a novel PRAAS subtype with immunodeficiency.

1 citation

humanproteomics

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Genetic & Genomic MedicineeLifePeer-reviewedOct 7, 2022

Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: a retrospective cohort study

Anne Hebert, Annet Simons, Janneke H. M. Schuurs-Hoeijmakers…·Caspar I. van der Made

This study evaluates the diagnostic value of trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity, identifying DNVs in immune-related genes and providing functional evidence for FBXW11 mutations.

13 citations

humanwhole-exome sequencing

𝕏 PostBluesky