Hans J. P. M. Koenen

The paper uses imaging-guided single-cell multiomics to identify shared autoreactive CD4+ T-cell responses in blood, lymph nodes, and tissues of patients with systemic autoimmune diseases.

This study shows CD8+ T cells drive myofibroblast activation and contraction through JAK/STAT3 and TGFβ signaling, not cytotoxicity, and suggests combined inhibition of these pathways could treat fibrosis.

This study evaluates the diagnostic value of trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity, identifying DNVs in immune-related genes and providing functional evidence for FBXW11 mutations.

This study identifies genetic variants influencing CCR5 expression on immune cells in HIV-positive and healthy individuals, showing cell-specific regulation and effects on inflammatory mediators.

The paper introduces Decon2, a method to deconvolute bulk blood eQTL effects into immune cell subpopulations, showing high concordance with experimental and single-cell studies.