Imaging guided single-cell multiomics unveils shared autoreactive CD4+ T-cell responses in blood, locoregional lymph node and affected tissues of patients with systemic autoimmunity
Theodoros Ioannis Papadimitriou, Prashant Singh, Arjan van Caam, Xuehui He, Konnie M. Hebeda, Birgitte Walgreen, E.L. Vitters, Pim Kloosterman, Laura J. A. Wingens, Klaas W. Mulder, Madelon C Vonk, I. Jolanda de Vries, Peter M van der Kraan, Ruben L. Smeets, Erik H.J.G. Aarntzen, , Rogier M. Thurlings
The paper uses imaging-guided single-cell multiomics to identify shared autoreactive CD4+ T-cell responses in blood, lymph nodes, and tissues of patients with systemic autoimmune diseases.
bioRxiv · Aug 23, 2026 · PreprintImmunology