Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces chassis for natural product discovery
Elena Heng, Lee Ling Tan, Dillon W. P. Tay, Yee Hwee Lim, Lay Kien Yang, Deborah Chwee San Seow, Chung Yan Leong, Veronica Wee Pin Ng, Siew Bee Ng, Yoganathan Kanagasundaram, Fong Tian Wong, Lokanand Koduru
This paper presents a cost-effective hybrid sequencing approach for assembling GC-rich Streptomyces genomes, enabling accurate biosynthetic gene cluster identification and revealing a new species.
bioRxiv · Dec 5, 2022 · PreprintGenomics