Author

Marissa N. Feeley

Broad InstituteORCID 0000-0002-2869-2315Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Annabel K. SangreeiD· 2 shared Audrey L GriffithiD· 2 shared John G. DoenchiD· 2 shared Kendall R Sanson· 2 shared Mudra HegdeiD· 2 shared Peter C. DeWeirdtiD· 2 shared Ruth E. HannaiD· 2 shared Alan HuangiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenetics

Annabel K. SangreeORCID

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2 papers

Recent·Most cited

GeneticsCellPeer-reviewedFeb 1, 2021

Massively parallel assessment of human variants with base editor screens

Ruth E. Hanna, Mudra Hegde, Christian R. Fagre…·John G. Doench

This paper uses CRISPR-Cas9 base editors in pooled screens to assess the functional impact of human variants, identifying loss-of-function mutations and drug sensitivity/resistance mutations.

314 citationstop 1%

humanCRISPR screen

𝕏 PostBluesky

GeneticsNature BiotechnologyPeer-reviewedJul 13, 2020

Optimization of AsCas12a for combinatorial genetic screens in human cells

Peter C. DeWeirdt, Kendall R Sanson, Annabel K. Sangree…·John G. Doench

This paper optimizes AsCas12a for combinatorial genetic screens in human cells by improving on-target and off-target activity and enabling higher-order multiplexing.

219 citationstop 1%

humanCRISPR screen

𝕏 PostBluesky