Author

Kendall R Sanson

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 4 Approach:experimental assay· 4 Research Focus:perturbation response prediction· 3 Research Focus:benchmarking· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

John G. DoenchiD· 4 shared Mudra HegdeiD· 4 shared Ruth E. HannaiD· 4 shared Annabel K. SangreeiD· 3 shared Christine StrandiD· 3 shared Peter C. DeWeirdtiD· 3 shared Audrey L GriffithiD· 2 shared Marissa N. FeeleyiD· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersGenetics

John G. DoenchORCID

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Author profile →

4 papers

Recent·Most cited

Massively parallel assessment of human variants with base editor screens

Ruth E. Hanna, Mudra Hegde, Christian R. Fagre, Peter C. DeWeirdt, Annabel K. Sangree, Zsofia M Szegletes, Audrey L Griffith, Marissa N. Feeley, Kendall R Sanson, Yossef Baidi, Luke W. Koblan, David R. Liu, James T. Neal, John G. Doench

This paper uses CRISPR-Cas9 base editors in pooled screens to assess the functional impact of human variants, identifying loss-of-function mutations and drug sensitivity/resistance mutations.

Cell · Feb 1, 2021Peer-reviewedGenetics

Optimization of AsCas12a for combinatorial genetic screens in human cells

Peter C. DeWeirdt, Kendall R Sanson, Annabel K. Sangree, Mudra Hegde, Ruth E. Hanna, Marissa N. Feeley, Audrey L Griffith, Teng Teng, Samantha M. Borys, Christine Strand, J. Keith Joung, Benjamin P. Kleinstiver, Xuewen Pan, Alan Huang, John G. Doench

This paper optimizes AsCas12a for combinatorial genetic screens in human cells by improving on-target and off-target activity and enabling higher-order multiplexing.

Nature Biotechnology · Jul 13, 2020Peer-reviewedGenetics

Genetic screens in isogenic mammalian cell lines without single cell cloning

Peter C. DeWeirdt, Annabel K. Sangree, Ruth E. Hanna, Kendall R Sanson, Mudra Hegde, Christine Strand, Nicole S. Persky, John G. Doench

The paper presents a method to generate isogenic cell pairs and screen them with CRISPR-Cas9 libraries to identify genetic interactions, demonstrating applications for BCL2L1, MCL1, and PARP1.

Nature Communications · Feb 6, 2020Peer-reviewedGenetics

Up, down, and out: optimized libraries for CRISPRa, CRISPRi, and CRISPR-knockout genetic screens

Kendall R Sanson, Ruth E. Hanna, Mudra Hegde, Katherine F. Donovan, Christine Strand, Meagan E. Sullender, Emma W Vaimberg, Amy B. Goodale, David E. Root, Federica Piccioni, John G. Doench

The paper evaluates and introduces optimized CRISPR libraries for knockout, interference, and activation screens, showing improved performance in gene function interrogation.

Nature Communications · Dec 17, 2018Peer-reviewedGenomics