Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control
Julien Chilloux, François Brial, Amandine Everard, David R. Smyth, Petros Andrikopoulos, Liyong Zhang, Hubert Plovier, Antonis Myridakis, Lesley Hoyles, José María Moreno‐Navarrete, Jèssica Latorre, Viviana Casagrande, Rossella Menghini, Blerina Ahmetaj‐Shala, Christine Blancher, , Marc‐Emmanuel Dumas
This study identifies trimethylamine (TMA) as a microbial compound that inhibits IRAK4, reducing inflammation and improving metabolic outcomes in high-fat diet conditions.
Nature Metabolism · Dec 8, 2025Peer-reviewedPhysiology