Dynamic Adaptation in Extant Porins Facilitates Antibiotic Tolerance in Energetic Escherichia coli
Sayak Mukhopadhyay, Romit Bishayi, Aakansha Shaji, Annie H. Lee, Rachit Gupta, Mohammad Mohajeri, Aditya Katiyar, Brendan McKee, Isabella R. Schmitz, Rachel Shin, Tanmay P. Lele, Pushkar P. Lele
This study identifies a mechanism by which Escherichia coli tolerate antibiotics through dynamic porin inhibition, independent of gene expression, involving electrostatic modifications.
bioRxiv · Mar 7, 2024 · PreprintMicrobiology