Alastair Mitchell Buchan

This study evaluates AZD1236, a dual MMP-9/-12 inhibitor, showing reduced infarct/hematoma volumes, improved neurological outcomes, and pain mitigation in stroke models.

The paper identifies a metabolically defined penumbra in hyperacute stroke using multimodal molecular profiling in a mouse model.

This paper develops shear-activated nanoparticles delivering nitroglycerin to improve ischaemic stroke outcomes by enhancing collateral vessel perfusion.

This study develops a new MRI protocol using 2DG-CESL to measure glucose metabolism in a rat stroke model and shows it provides a biomarker of disturbed metabolism with high effect size.

This study shows rapamycin reduces brain pericyte contraction during ischemia but not viability, improving capillary diameter and openness after stroke.

This study shows that post-recanalization rapamycin treatment improves cerebral blood flow and functional outcomes in rats after ischemic stroke.

This study investigates whether fasting after ischemic stroke reduces infarct volume and inflammation in rats.