Barbara R. Migeon

The paper investigates XIST repression on the future active X in human and bovine preimplantation embryos using single-cell RNA sequencing and qRT-PCR, identifying potential repressors and timing of XIST expression.

The paper identifies autosomal genes on chromosomes 1 and 19 involved in X inactivation, showing their non-random genomic organization and evolutionary conservation.

The paper identifies a critical genomic region on chromosome 19 that protects the active X chromosome from XIST-mediated silencing, linking its disruption to embryonic female loss.