Bernard A.J. Roelen

The paper investigates XIST repression on the future active X in human and bovine preimplantation embryos using single-cell RNA sequencing and qRT-PCR, identifying potential repressors and timing of XIST expression.

This study shows that Cfap53 is essential for forming the first zygotic microtubule organizing center in zebrafish embryos, but not for later cell divisions.

Sperm DNA damage leads to genomic defects in embryos through chromosome fragmentation and segregation errors.