Leonard E. Bäcker

The infection cycle of the haloarchaeal virus HFTV1 is tightly regulated and strongly inhibits motility of its host

This paper analyzes the transcriptome of an archaeal virus and its host during infection, revealing tight temporal regulation and a role for anti-sense RNAs in viral gene expression, along with host motility suppression.

Phage-mediated just-in-time circuit amplification and delivery for recombinant expression of toxic proteins

This paper develops a phage-mediated system for just-in-time amplification and delivery of production circuits in E. coli to express toxic proteins without chemical inducers or leaky expression.

Tuning and functionalization of logic gates for time resolved programming of bacterial populations

The paper engineers a tunable timer circuit in E. coli to enable time-resolved programming of bacterial populations through synthetic pathways and asynchronous timers.