Abram Aertsen

This paper describes a method to engineer Escherichia coli to exhibit linear proliferation by using protein aggregates that produce a conditionally essential metabolite.

This study shows that protein aggregation in E. coli drives aging by reducing intracellular space, leading to larger cell sizes and asymmetric divisions.

This paper develops a phage-mediated system for just-in-time amplification and delivery of production circuits in E. coli to express toxic proteins without chemical inducers or leaky expression.

The paper engineers a tunable timer circuit in E. coli to enable time-resolved programming of bacterial populations through synthetic pathways and asynchronous timers.