Author

Kaitlyn A. Lagattuta

Broad InstituteORCID 0000-0002-2950-6238Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:eQTL / molecular QTL mapping· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Aparna NathaniD· 2 shared Cristian ValenciaiD· 2 shared José Alquicira-HernándeziD· 2 shared Joseph E. PowelliD· 2 shared Joyce B. KangiD· 2 shared Kazuyoshi IshigakiiD· 2 shared Laurie RumkeriD· 2 shared Seyhan YazariD· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Aparna NathanORCID

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3 papers

Recent·Most cited

GeneticsNature GeneticsPeer-reviewedSep 26, 2024

Identifying genetic variants that influence the abundance of cell states in single-cell data

Laurie Rumker, Saori Sakaue, Yakir Reshef…·Soumya Raychaudhuri

The paper introduces GeNA, a tool to identify genetic variants influencing cell state abundance in single-cell data, finding five loci associated with immune cell state shifts.

19 citationstop 3%

humanscRNA-seq

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Genetic & Genomic MedicineNature GeneticsPeer-reviewedNov 30, 2023

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

Joyce B. Kang, Amber Z. Shen, Saisriram Gurajala…·Joseph E. Powell

The paper maps cell-type-specific eQTLs for HLA genes across multiple tissues and identifies dynamic regulation of HLA-DQ genes in immune cells.

49 citationstop 1%

humanbulk RNA-seq

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Genetic & Genomic MedicineNature GeneticsPeer-reviewedMar 24, 2022

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Kazuyoshi Ishigaki, Kaitlyn A. Lagattuta, Yang Luo…·Soumya Raychaudhuri

The paper investigates how HLA alleles influence TCR CDR3 composition and finds strong associations between HLA risk alleles and specific CDR3 amino acid features linked to autoimmune diseases.

105 citationstop 1%

humanstatistical model

𝕏 PostBluesky