Cristian Valencia

Identifying genetic variants that influence the abundance of cell states in single-cell data

The paper introduces GeNA, a tool to identify genetic variants influencing cell state abundance in single-cell data, finding five loci associated with immune cell state shifts.

Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs

The paper demonstrates that modeling single-cell perturbation states improves detection of reQTLs by accounting for cell-level heterogeneity in perturbation responses.

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

The paper maps cell-type-specific eQTLs for HLA genes across multiple tissues and identifies dynamic regulation of HLA-DQ genes in immune cells.

Antiviral Antibody Epitope Selection is a Heritable Trait

The paper identifies heritable antibody epitopes and genetic loci associated with EBV immune responses and viral load control using twin and SNP-genotyped data.

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

The paper uses hiPSC transcriptomics to study neuronal differentiation and maturation across multiple conditions and develops a tool to estimate neuronal maturity.

Regional heterogeneity in gene expression, regulation and coherence in hippocampus and dorsolateral prefrontal cortex across development and in schizophrenia

The paper identifies regional differences in gene expression and regulation in hippocampus and dorsolateral prefrontal cortex across development and in schizophrenia using RNA-seq data from 900 samples.