Author

Saisriram Gurajala

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:fine-mapping· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Joyce B. KangiD· 2 shared Kazuyoshi IshigakiiD· 2 shared Laurie RumkeriD· 2 shared Michelle L. CurtisiD· 2 shared Aaron J. DeutschiD· 1 shared Aaron J. WyseiD· 1 shared Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network· 1 shared Adam T. Chicoine· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Joyce B. KangORCID

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2 papers

Recent·Most cited

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

Joyce B. Kang, Amber Z. Shen, Saisriram Gurajala, Aparna Nathan, Laurie Rumker, Vitor R. C. Aguiar, Cristian Valencia, Kaitlyn A. Lagattuta, Fan Zhang, Anna Helena Jonsson, Seyhan Yazar, José Alquicira-Hernández, Hamed Khalili, Ashwin N. Ananthakrishnan, Karthik A. Jagadeesh, , Joseph E. Powell

The paper maps cell-type-specific eQTLs for HLA genes across multiple tissues and identifies dynamic regulation of HLA-DQ genes in immune cells.

Nature Genetics · Nov 30, 2023Peer-reviewedGenetic & Genomic Medicine

A statistical genetics guide to identifying HLA alleles driving complex disease

Saori Sakaue, Saisriram Gurajala, Michelle L. Curtis, Yang Luo, Wanson Choi, Kazuyoshi Ishigaki, Joyce B. Kang, Laurie Rumker, Aaron J. Deutsch, Sebastian Schönherr, Lukas Forer, Jonathon LeFaive, Christian Fuchsberger, Buhm Han, Tobias L. Lenz, , Soumya Raychaudhuri

This paper provides a statistical genetics guide for imputing HLA alleles from genotype data and offers best practices for association testing to identify HLA variants driving complex diseases.

bioRxiv · Aug 24, 2022 · PreprintGenetics