The mechanism of peptidoglycan O-acetylation in Gram-negative bacteria typifies bacterial MBOAT-SGNH acyltransferases
Alexander C. Anderson, Bailey J. Schultz, Eric D. Snow, Ashley S. Brott, Stefen Stangherlin, Tyler Malloch, J. R. London, Suzanne Walker, Anthony J. Clarke
This study elucidates the mechanism of MBOAT-SGNH acyltransferases in Gram-negative bacteria, showing that a tyrosine-containing peptide shuttles acyl groups from MBOAT to SGNH active sites for peptidoglycan O-acetylation.
Journal of Biological Chemistry · Apr 23, 2025Peer-reviewedBiochemistry