Ángeles Arzalluz-Luque

MOSim: bulk and single-cell multi-layer regulatory network simulator

MOSim generates synthetic bulk and single-cell multi-omics datasets for benchmarking methods that analyze regulatory networks across various omics layers.

SQANTI3: curation of long-read transcriptomes for accurate identification of known and novel isoforms

SQANTI3 extends long-read transcriptome quality control with transcript-end subcategories, a short-read TSS ratio, rules or random-forest filters and a rescue module, raising SIRV-benchmarked F-score stepwise.

Acorde: unraveling functionally-interpretable networks of isoform co-usage from single cell data

Acorde identifies co-expression networks of alternative isoforms from single-cell data and detects co-differential isoform usage in neural cell types.

tappAS: A comprehensive computational framework for the analysis of the functional impact of differential splicing

The paper introduces tappAS, a framework for analyzing the functional impact of differential splicing, showing AltTP plays a major role in neural development by altering protein function and regulation.