CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer
Beatrice Gini, Philippe Gui, Wei Wu, Daniel Lucas Kerr, Lisa Tan, Dora Barbosa, Victor R. Olivas, Paul Allegakoen, Carlos Gomez, Patrick R. Halliday, Sarah Elmes, Veronica Steri, Turja Chakrabarti, Trever Grant Bivona, Collin M. Blakely
This study shows that CDK4/6 upregulation causes DNA replication stress and genomic instability, leading to resistance to EGFR inhibitors in lung cancer, and suggests combining CDK4/6 and EGFR inhibitors as a treatment.
bioRxiv · Mar 12, 2024 · PreprintCancer Biology