Beatrice Gini

This study uses single-cell lineage tracing and RNAseq to identify pre-existing resistant tumor subclones in lung cancer models and their transcriptional programs, revealing mechanisms of therapy resistance.

This study shows that CDK4/6 upregulation causes DNA replication stress and genomic instability, leading to resistance to EGFR inhibitors in lung cancer, and suggests combining CDK4/6 and EGFR inhibitors as a treatment.

The paper investigates genetic epistasis in EGFR-mutant lung cancers using over 2,000 cases, showing that genetic combinations, not single drivers, dominate tumor progression and clinical outcomes.