Author

Owen Kane

Children's Hospital of PhiladelphiaORCID 0000-0002-2994-7578Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1

Frequent Co-Authors

Rebecca C. Ahrens‐NicklasiD· 2 shared Amaliris GuerraiD· 1 shared Amanda Kuhs· 1 shared Arron F HalliD· 1 shared Beverly L. DavidsoniD· 1 shared Carlo Castruccio CastracaniiD· 1 shared Cathleen M. LutziD· 1 shared Colleen S. SteiniD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Rebecca C. Ahrens‐NicklasORCID

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2 papers

Recent·Most cited

NeuroscienceMolecular TherapyPeer-reviewedAug 22, 2024

Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mousemodel of Multiple Sulfatase Deficiency

Vi Pham, Lucas Tricoli, Xinying Hong…·Rebecca C. Ahrens‐Nicklas

This study shows that SUMF1 gene therapy via hematopoietic stem cell transplant improves biochemical and functional outcomes in a mouse model of Multiple Sulfatase Deficiency.

3 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceMolecular TherapyPeer-reviewedApr 5, 2022

Neuronal genetic rescue normalizes brain network dynamics in a lysosomal storage disorder despite persistent storage accumulation

Rebecca C. Ahrens‐Nicklas, Luis Tecedor, Arron F Hall…·Beverly L. Davidson

This study shows that restoring Cln3 in neurons normalizes brain network dysfunction in CLN3 disease despite persistent storage accumulation, suggesting neuronal loss-of-function, not storage, drives neurologic symptoms.

13 citations

mouseelectronic health records

𝕏 PostBluesky