Colleen S. Stein

This study shows that Mitoregulin (Mtln) protects mitochondrial membrane integrity and reduces cardiac ischemia-reperfusion injury by stabilizing cardiolipin and preventing membrane damage.

This study identifies Txlnb as a centrosome-adapter protein that mediates proteostasis in cardiomyocytes, linking centrosomes to the ubiquitin-proteasome system and influencing cardiac stress responses.

The paper shows Mitoregulin self-associates into hexameric pore-like structures through co-immunoprecipitation, modeling, and gel analysis.

This study shows MIRO1 regulates VSMC proliferation and neointima formation by controlling mitochondrial positioning, ATP production, and ETC function.

This study identifies an upstream alternative polyadenylation event in SCN5A that generates a short transcript encoding a mitochondria-localized NaV1.5 N-terminal fragment, which affects cardiomyocyte respiration.

This study shows that restoring Cln3 in neurons normalizes brain network dysfunction in CLN3 disease despite persistent storage accumulation, suggesting neuronal loss-of-function, not storage, drives neurologic symptoms.