Aaron Tan

This study benchmarks tumor-naive ctDNA detection and quantification methods using WGS and methylation data from cancer patients, identifying performance trade-offs and optimal integration strategies.

This study shows chronic antipsychotic treatment increases addiction vulnerability in rats and humans by altering D2-MSN spine morphology and reward-seeking behavior.

The paper identifies a cortico-thalamic loop between the medial prefrontal cortex and anteromedial thalamus that regulates motivation, reinforcement, and dopaminergic activity through reciprocal connectivity and feedback.