Satoshi Ikemoto

Supramammillary projections to the lateral preoptic area drive dopamine release and active behavior

The paper identifies the SuM[->]LPO pathway as a circuit that modulates dopamine release and active behavior through interactions with mesolimbic dopamine signaling.

Parabrachial-amygdala circuit cooperates with a posterior striatal area to drive opioid withdrawal aversion

This study identifies a PB-CeC circuit and posterior striatal area as cooperative drivers of opioid withdrawal aversion through chemogenetic inhibition experiments.

Reinforcing Nicotine Doses Activate Supramammillary VGluT2 Neurons in Mice

The paper identifies supramammillary VGluT2 neurons expressing β2 nAChR as a circuit engaged by reinforcing nicotine doses in mice.

Orexinergic Input to the Supramammillary Region Links Threat Salience to Approach Behavior and Dopamine Release

The paper identifies an orexin-to-supramammillary region pathway that links threat salience to approach behavior and dopamine release.

Nuclear GAPDH in cortical microglia mediates stress-induced cognitive inflexibility

This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.

Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction

This study identifies a pathway involving supramammillary neurons projecting to the septum that regulates dopamine and motivation for environmental interaction in mice.

Medial Prefrontal Cortex Interacts with the Anteromedial Thalamus in Motivation and Dopaminergic Activity

The paper identifies a cortico-thalamic loop between the medial prefrontal cortex and anteromedial thalamus that regulates motivation, reinforcement, and dopaminergic activity through reciprocal connectivity and feedback.