Author

Ernst‐Jan M. Speel

Maastricht University Medical CentreORCID 0000-0002-3016-2989Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Aitor Rodríguez‐CasanovaiD· 1 shared Alexandre HarléiD· 1 shared Alexis RapiniD· 1 shared Anes Hadjadj AouliD· 1 shared Ángel Díaz‐LagaresiD· 1 shared Ann HoebeniD· 1 shared Anne‐Marie C. DingemansiD· 1 shared Annelies Claeys· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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1 shared paperGenetic & Genomic Medicine

Aitor Rodríguez‐CasanovaORCID

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2 papers

Recent·Most cited

Longitudinal tumor ecosystem mapping defines glioblastoma treatment trajectories

Maxime Vanmechelen, Pouya Nazari, Jan C. Beckervordersandforth, Chiara Caprioli, Daphne J. G. Leunissen, Basiel Cole, Carmen Bravo González‐Blas, Brecht Decraene, Yanti De Visser, G Shankar, Maikel Verduin, daniele Pantano, Sien Bevers, Tom Moors, Shanna Zielinski, , Frederik De Smet

This study maps glioblastoma tumor ecosystems over time using spatial single-cell profiling to identify prognostic subgroups and treatment responses.

bioRxiv · Mar 7, 2026 · PreprintCancer Biology

Analytical Validation of a Pan-Cancer NGS Assay for In-House Liquid Biopsy Testing: An International Multicenter Study

Gaëlle Lescuyer, Alexandre Harlé, Hari Shankar Kumar, Pantelis Constantoulakis, Nicole Pfarr, Ellen Heitzer, Clémence Michon, Gianluca Russo, Ernst‐Jan M. Speel, Marie Piecyk, Marie Husson, Georgia Christopoulou, Eva-Maria Mayr, Mai-Lan Koppermann, Christophe Passot, , Lea Francoise Payen

This study validates a pan-cancer NGS assay for liquid biopsy testing across multiple centers, showing high sensitivity and specificity for detecting genomic alterations in cfDNA.

Journal of Molecular Diagnostics · Sep 25, 2025Peer-reviewedGenetic & Genomic Medicine