Disrupting IFIT1-STAT2 viral evasion synergy yields live-attenuated flavivirus with enhanced immune priming
Amporn Suphatrakul, Warangkana Chantima, Pratsaneeyaporn Posiri, Nittaya Srisuk, Rapirat Nantachokechawapan, Nattawadee Panyain, Suppachoke Onnome, Tiwa Rotchanapreeda, Benyapa Thanatummatis, Nopporn Sittisombut, Poonsook Keelapang, Gavin Robert Screaton, Juthathip Mongkolsapaya, Wanwisa Dejnirattisai, Bunpote Siridechadilok
The paper disrupts the synergistic immune evasion of dengue virus by targeting IFIT1-STAT2, resulting in an attenuated virus that enhances innate immune priming.
bioRxiv · Jun 5, 2026 · PreprintMicrobiology