Gavin Robert Screaton

Dengue virus 2 lacking N153 glycosylation displayed enhanced recognition by neutralizing antibodies

The paper shows a dengue virus mutant lacking N153 glycosylation is more susceptible to neutralizing antibodies, as evidenced by increased Fab occupancy and slower dissociation rates.

Disrupting IFIT1-STAT2 viral evasion synergy yields live-attenuated flavivirus with enhanced immune priming

The paper disrupts the synergistic immune evasion of dengue virus by targeting IFIT1-STAT2, resulting in an attenuated virus that enhances innate immune priming.

Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny

The paper reprocesses SARS-CoV-2 genomic data to correct systematic errors in phylogenies using a novel assembly tool, resulting in a cleaner global tree of 4.47 million samples.

Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera

The paper compares SARS-CoV-2 antigenicity across assays and in human and animal model sera, finding similar immunodominance patterns and antigenic maps but differences in titer magnitude and assay-specific fold change.

CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever

This study determines the tetrameric and hexameric structures of secreted dengue NS1, revealing their quaternary organization and how antibody binding affects their stability.

Genome-first detection of emerging resistance to novel therapeutic agents for SARS-CoV-2

The paper identifies mutations in SARS-CoV-2 variants that confer resistance to monoclonal antibodies by analyzing genomic data and validating their impact on antibody neutralization.