C-Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2'-OH
Dipanwita Banerjee, Lu Xiao, Pavitra S. Thacker, Jayanta Kundu, Muthiah Manoharan, Eric T. Kool
This paper investigates how C-nucleoside modifications in RNA reduce nucleophilicity at the 2'-OH position, thereby stabilizing RNA against cleavage.
ACS Central Science · Oct 28, 2025Peer-reviewedBiophysics