Eric T. Kool

Capsular polysaccharide can sensitize bacteria to non-antibiotic drugs

The paper shows that the K5 capsular polysaccharide of E. coli Nissle 1917 sensitizes it to thioridazine and related antipsychotics, revealing CPS as a vulnerability under non-antibiotic drug pressure.

Fluorogenic Covalent Probes for RNA

This paper introduces fluorogenic covalent probes for RNA that offer high selectivity over DNA and significant fluorescence enhancement for imaging and analysis.

DNA Content and DNA Damage in Raw and Heat-processed Foods

The paper assesses DNA content and damage in raw and heat-processed foods, finding significant DNA damage increases from cooking and potential cytotoxic effects in human cells.

C-Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2'-OH

This paper investigates how C-nucleoside modifications in RNA reduce nucleophilicity at the 2'-OH position, thereby stabilizing RNA against cleavage.

Sequence-Specific Installation of Aryl Groups in RNA via DNA-Catalyst Conjugates

This paper describes a DNA-catalyst conjugate method for sequence-specific arylation of RNA, enabling labeling and modification with high yield.

RNA 2'-OH modification with stable reagents enabled bynucleophilic catalysis

This study introduces stable electrophilic reagents for RNA 2'-OH modification using nucleophilic catalysis, achieving high yields and improved stability.

Integrating transcription factor abundance with chromatin accessibility in human erythroid lineage commitment

The paper introduces InTAC-seq to quantify chromatin accessibility and transcription factor abundance in fixed cells, showing GATA1's role in erythroid lineage commitment.

Dynamic Regulation of RNA Structure in Mammalian Cells

The paper maps RNA structuromes in three subcellular compartments and identifies LIN28A as an m6A anti-reader, revealing dynamic RNA structure regulation.